mapk inhibitor library Search Results


mapk inhibitor library  (TargetMol)
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map kinase inhibitor library l3400  (Selleck Chemicals)
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Selleck Chemicals map kinase inhibitor library l3400
Graphical representation of primary screen results of the Published Kinase Inhibitor Set ( A ) and the SelleckChem <t>MAPK</t> Inhibitor Library ( B ) against Histoplasma capsulatum . Each individual compound was tested, in duplicate, at a final concentration of 5 μM. Log phase Hc WU15 yeasts were seeded in 96 well plates at a density of 1 × 10 6 yeasts/mL in HMM/uracil. Compounds were diluted in DMSO and added to each well at a final DMSO concentration of 0.5%. Plates were incubated at 37 °C and 5% CO 2 with twice-daily shaking to improve aeration. OD 595 readings were taken on day 0 and day 4. The results for each compound are shown as average percent growth inhibition over the four day time period relative to the DMSO control. All compounds showing greater than 50% growth inhibition at day 4 are identified.
Map Kinase Inhibitor Library L3400, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mapk+inhibitor+library/MAPK+Inhibitor+Library/pmc08532743-125-5-10
Average 94 stars, based on 1 article reviews
map kinase inhibitor library l3400 - by Bioz Stars, 2026-09
94/100 stars
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mapk inhibitor library  (Aladdin Scientific Corporation)
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• A unique collection of 258 small molecule inhibitors used for MAPK signaling research.• Targets MEK, Raf, p38 MAPK, JNK, ERK, etc.• Structurally diverse, medicinally active, and cell permeable.• Rich documentation with structure and customer
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Graphical representation of primary screen results of the Published Kinase Inhibitor Set ( A ) and the SelleckChem MAPK Inhibitor Library ( B ) against Histoplasma capsulatum . Each individual compound was tested, in duplicate, at a final concentration of 5 μM. Log phase Hc WU15 yeasts were seeded in 96 well plates at a density of 1 × 10 6 yeasts/mL in HMM/uracil. Compounds were diluted in DMSO and added to each well at a final DMSO concentration of 0.5%. Plates were incubated at 37 °C and 5% CO 2 with twice-daily shaking to improve aeration. OD 595 readings were taken on day 0 and day 4. The results for each compound are shown as average percent growth inhibition over the four day time period relative to the DMSO control. All compounds showing greater than 50% growth inhibition at day 4 are identified.

Journal: Antibiotics

Article Title: Kinase Inhibitor Library Screening Identifies the Cancer Therapeutic Sorafenib and Structurally Similar Compounds as Strong Inhibitors of the Fungal Pathogen Histoplasma capsulatum

doi: 10.3390/antibiotics10101223

Figure Lengend Snippet: Graphical representation of primary screen results of the Published Kinase Inhibitor Set ( A ) and the SelleckChem MAPK Inhibitor Library ( B ) against Histoplasma capsulatum . Each individual compound was tested, in duplicate, at a final concentration of 5 μM. Log phase Hc WU15 yeasts were seeded in 96 well plates at a density of 1 × 10 6 yeasts/mL in HMM/uracil. Compounds were diluted in DMSO and added to each well at a final DMSO concentration of 0.5%. Plates were incubated at 37 °C and 5% CO 2 with twice-daily shaking to improve aeration. OD 595 readings were taken on day 0 and day 4. The results for each compound are shown as average percent growth inhibition over the four day time period relative to the DMSO control. All compounds showing greater than 50% growth inhibition at day 4 are identified.

Article Snippet: The PKIS library and the MAP kinase inhibitor library L3400 (SelleckChem, Houston, TX, USA) were provided as 1 mM stocks in DMSO.

Techniques: Concentration Assay, Incubation, Inhibition, Control